can u inject ativan? i had something injected into me at the hospital for my surgery once and at the ER a couple times, they said it was similar to valium.. if u have any info on this lemme know.
It very well could have been Valium(Diazepam), as well as Ativan(Lorazepam) that you were given.
The injectable forms of benzodiazepines differ from the oral forms. I don't have definitive information concerning the formulas for the IV form/sublingual(under the tongue) and common tablets, but they all differ.
It's very risky to inject anything but the IV form, as there are fillers and binders present of unknown substances.
From Martindale:The Complete Drug Reference comes the following:(Lorazepam). A white or almost white, crystalline powder. It exhibits polymorphism. Practically insoluble in water; sparingly soluble in alcohol; sparingly or slightly soluble in dichloromethane. Store in airtight containers. Protect from light.
(Lorazepam). A white or practically white, practically odourless powder. Insoluble in water; sparingly soluble in alcohol; slightly soluble in chloroform. Store in airtight containers. Protect from light.
It doesn't appear that common types of procedures for freebase extraction would work well here.
More fromMartindale's:Solubility.
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The solubility of lorazepam in fluids for intravenous administration (water, glucose injection, lactated Ringer's injection, and sodium chloride injection) was greatest in glucose injection (5%) at 62micrograms/mL and lowest in sodium chloride injection (0.9%) at 27micrograms/mL;<SUP> </SUP>these differences in solubility appeared to be pH related. Commercial injections are reported to contain polyethylene glycol in propylene glycol to overcome this poor solubility. However, precipitation has been noted in solutions prepared by dilution of lorazepam injection with sodium chloride injection (0.9%) to a concentration of 500micrograms/mL. One group of workers have reported that they had overcome such problems with precipitation by using glucose injection (5%) as a diluent and by avoiding final concentrations of lorazepam between 0.08mg/mL and 1mg/mL. It was suggested that the propylene glycol in the mixture might account for the unusual concentration effect. Such recommendations have been adopted by another group although they observed that precipitation occurred if a formulation of lorazepam containing 4mg/mL was used to prepare the injection; no precipitation was noted when a formulation containing 2mg/mL was used. The group also commented that, in the USA, the manufacturers of lorazepam injection advise that admixtures should be prepared with the 2mg/mL formulation only.
RxList shows the following formula for injectable Ativan(Lorazepam):Injection: Lorazepam injection, a benzodiazepine with antianxiety and sedative effects, is intended for intramuscular or intravenous route of administration. Lorazepam is a nearly white powder almost insoluble in water. Each ml of sterile Ativan injection contains either 2.0 or 4.0 mg of lorazepam, 0.18 ml polyethylene glycol 400 in propylene glycol with 2.0% benzyl alcohol as preservative.
I could speculate as to what fillers/binders are used for standard tablets, as well as substances toaid the sublingual variety's absorption, but I will not. When dealing with topics of this variety, certainty is a must.However, it is common to use lactose as a filler in benzo tablets, but I do not know if this is the case with Ativan(Lorazepam).
Short version: Just eat them, or try 'under the tongue' absorption.
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