Downers crosstolerance

[mark_v]

Maybe a dumb question, but if you have build up a high tolerance for
Zopiclone, does it means you have a tolerance for Zolpidem ?

Because they're not benzo's, and i don't know how they affect each oter..



I'm asking because i took 3 Zopiclon's 7.5 mgs every night for about 3
months, and now i switched to Zolpidem, but it doesn't affect me at
all...

[Lehendakari]

SWIM got a good amount of downers of every kind. He has clonopin, xanax, soma, phenobarbital and zolpidem. His idea is to have a bunch of different downers for not developing tolence to any of them.

He know about cross-tolerance between benzos but nothing else.

Carisoprodol is not related to benzos, but he tried it yesterday and had very benzo-like effects maybe a bit better. Also phenobarbital acts pretty much the same way benzos do and zolpidem is a different story.

So swim knows about addiction potential so he doesn't do the very often, and doesn't wanna develop tolerance, so he never does benzos more than once.

He is doing this:

Day 1: xanax 1 mg........
Day 2: abstinence
Day 3: Soma 700 mg
Day 4: Clonopin 1 mg
Day 5: abstinence
Day 6:?
Day 7:?
He hasn't yet tried phenobarbital and zolpidem but plans to do them.

All drugs above has great effects for swim a he is falling in love with downers but he is not going to be doing them so often (he is just experimenting).

The question is that this downer change will avoid tolerance or it is just a waste of time, and swim will probably develop tolerance pretty quick to every downer.

Note that swim always combines downers with MJ which finds it wonderful and he often does ritalin during the day at work.

[MrMouse]

All Benzo's and Z-Hypnotics (Zopiclone/Zolpidem) are cross tolerant to a fair degree.
At such small infrequent dosing I don't forsee any immediate issues.

I have no idea about Phen or Soma ... do your homework if you haven't already :)

[Lehendakari]

All chemicals listed in the first post have cross-tolerance. SWIM has noticed.

Ambien after doing benzo will have less effect. SWIM thought that zolpidem acted on different receptors than benzos but it doesn't:

In 1990, Pritchett and Seeburg noted that zolpidem binds with high affinity to the α (http://en.wikipedia.org/wiki/GABA_A_receptor)1, with medium affinity to the α2, α3-GABAA receptor (http://en.wikipedia.org/wiki/GABA_A_receptor) subunits, and found that it had no affinity for the α5 subunit.[1] (http://en.wikipedia.org/wiki/Zolpidem#endnote_gabaa1,2,3) Two years later, zolpidem was noted to have a high affinity (http://en.wikipedia.org/wiki/Affinity) for ω1; benzodiazepine receptors, a low affinity for ω2 and a very low affintity for ω3, respectively by Ruano et al in 1992.[2] (http://en.wikipedia.org/wiki/Zolpidem#endnote_omega1-2-3bzd) In other words, it has the highest affinity for ω1 binding sites on α-1GABAA receptor subunits, and it is this that mediates (http://en.wiktionary.org/wiki/mediate) its sedative and weak anticonvulsant properties.[3] (http://en.wikipedia.org/wiki/Zolpidem#endnote_a1gabaa-selective)

Barbiturates act in different place:

The binding site for benzodiazepines is distinct from the binding site for barbiturates (http://en.wikipedia.org/wiki/Barbiturate) and GABA on the GABA receptor.

but have cross-tolerance with benzos as far as swim can tell for his experiences.

Sources:

http://en.wikipedia.org/wiki/Zolpidem

http://en.wikipedia.org/wiki/Xanax