The Midazolam (Versed) MetaThread

[feenixdung]

I have a vial of Midazolam (Versed) 10mg is it possible to drink the injectable form of this drug? Will it change the effect of the drug and answers would be helpful

[Gahaba22]

I would think that you could. However, with so little payoff, I would not risk it. You have to look at the risk/benefit.



geeb

[BA]

IV sedation for mechanical ventilation: load with 0.2 mg/Kg, then begin infusion with 2 mcg/Kg/min. Increase infusion rate every 30 minutes in increments of 1 mcg/Kg/min. until desired level of sedation is obtained. Concurrent sedation with morphine is used in children.


IM sedation for procedure or pre-op: 0.08 mg/Kg/dose, give 1 dose only.


Rectal sedation: 0.3 mg/Kg/dose, diluted in 5 ml normal saline, give one dose only

Metabolized by hydroxylation and conjugation prior to excretion in urine. Metabolites have little sedative effect.

Toxicity Respiratory depression (particularly with excessive doses or rapid IV infusions), hiccoughs, nausea, vomiting, headache, drowsiness.

References Benitz & Tatro, Pediatric Drug Handbook, 2nd edition, page 92, 1988


VERSED is a sedative (http://sedative) that requires administration (http://administration) and individualization of dosage. Clinical experience (http://experience) has shown VERSED to be 3 to 4 times as potent (http://potent) as diazepam. BECAUSE SERIOUS AND LIFE-THREATENING CARDIORESPIRATORY ADVERSE EVENTS HAVE BEEN REPORTED, PROVISION FOR MONITORING, DETECTION AND CORRECTION OF THESE REACTIONS MUST BE MADE FOR EVERY PATIENT TO (http://TO) WHOM VERSED INJECTION IS ADMINISTERED, REGARDLESS OF AGE OR (http://OR) HEALTH STATUS. Excessive single doses or rapid intravenous (http://intravenous)administration (http://administration) may result in respiratory (http://respiratory) depression, airway obstruction (http://obstruction) and/or arrest. The potential (http://potential) for these latter effects is increased in debilitated patients, receiving concomitant (http://concomitant) medications capable of depressing the CNS, and patients without an endotracheal tube (http://tube) but undergoing a procedure (http://procedure) involving the upper airway (http://airway) such as endoscopy (http://endoscopy) or dental (http://dental)


Reactions such as agitation, involuntary (http://color=#0000ffinvoluntary) movements, hyperactivity (http://color=#0000ffhyperactivity) and combativeness have been reported in adult (http://color=#0000ffadult) and pediatric (http://color=#0000ffpediatric) patients. Should such reactions occur, caution should be exercised before continuing administration (http://color=#800080administration) of VERSED

[mark_v]

Anyone ever tried this ?

I came across of 130 of these, 7.5mg and 15 mg.

Do they have any recreational value ?

I heard they're pretty strong, but 15 mg dormicum = 20 mg Diazepam.

So i'm a bit confused http://www.drugs-forum.co.uk/forum/smileys/smiley5.gif

[BlueMystic]

They do have recreational value. Some people like to IV these. As they are one of the only pill form benzo's that can be safely IV'd. Edited by: BlueMystic

[calmascanbe]

I've had an anxiety and panic disorder for 30 some odd years and have tried many benzo's ,but I have never tried versed. On other sites some people claim it is like taking 6-8 mg. of xanax. Can anyone give me any clues to this benzo? I'm having a hard time believing the claim compaired to taking that much xanax to 7.5 mg. of midazolam.Any info would be great ,thanks.
I'm new here and I hope this is not a stupid question.

[IHrtHalucingens]

i have heard that it is very strong. im not sure of the ratio with xanax, but it is used widely as an anesthetic. Are you speaking of a pill? i have never heard of a pill, only a syrup/liquid. i would think it would be too strong for anxiety issues, maybe at a very very small dose. But anyway it is a much stronger benzo compared to xanax and triazolam.

[calmascanbe]

Thanks- you can find them at 7.5mg. on some international OP's .I'm mainly curious to try to save some cash instead of what I have to pay now.

[IHrtHalucingens]

hmm id try those if i was still into that. i have taken massive amounts of xanax before and felt barely anything( when i had a tolerance), but my bet is that even with a tolerance u take a couple of those and you'll def be feeling it. That pill is probably used for surgeries and things where they need to knock u unconcious for a procedure. u probably take like 1 an hour before the operation and another right before. so with a tolerance and for recreational use id say that same dose would be fun. let me know how it works if u try it. it may be worth one last benzo binge.haha

[calmascanbe]

I just might try them. If I do I will tell you all about it.

[calmascanbe]

Does anyone know more about the effects of this drug? I'm very curious and am dwelling on using them. Any info would be very wecome. Thanks.

[oggy]

Swims use them and thinks their poo poo. Swim has the roche 7.5mg tabs and they dont even put swim to sleep, he can take 10 and not feel much.

Swim is going to desolve 10 of them and drink it and see if it does anything this morning.

[calmascanbe]

Now I'm realy in limbo about using them.
mark v - do they work for anxiety and are there any side affects that might stop me from trying them? Can you tell me how they compair to xanax or valium ? Thanks

[mark_v]

I don't think they are usable for anxiety, because they are sleeping pills.
Maybe in a small dose, you feel relaxed, kinda like Lorazepam.
But there are better benzo's out there for anxiety IMO.
Versed is mostly used for operations, as an anesthetic and are rarely prescribed by any doc or psych for sleeping disorder because of the nasty withdrawl effects it causes, even after a week.
SWIM used them once for about 10 days in row and got withdrawel symptomes during the day.
So be carefull with this one, it's not like most other benzo's.
Way too strong and I would not recommed using them recreationally, because they are VERY addictive and withdrawel symptones you get are real nasty and are surfacing even after using them for a short period.
My advice : stay away from them ! ;-)

[calmascanbe]

Thanks mark v , You have made my decission for me.

[mark_v]

All i know is that SWIM's friens keep begging him for some Versed.
They prefer it over Xanax.
But swim just used them to get some sleep, and that helped a lot.
Far more better then Ambien... for sleeping that is..

[dr ACE]

any one herd of this one supposedly its a replacment for temazepam

[Abrad]

SWIM was given it when getting some teeth out, it was strong, very strong.

[Jatelka]

As far as SWIJ is aware Versed is only available as a parenteral formula and (in the US) as a syrup which is only liscensed for paediatric sedation. It is a a schedule IV drug in the US and schedule 4 in the UK. She does not believe it exists in tablet form.

(mostly) From rxlist:

VERSED is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral form for iv or im injection. Each mL contains midazolam hydrochloride equivalent to 1mg or 5mg midazolam compounded with 0.8% sodium chloride nd 0.01% edetate disodium, with 1% benzyl alcohol as preservative.

Midazolam is a white to light yellow crystalline compound which is insoluble in water. The hydrochloride salt of midazolam, which is formed in situ , IS water soluble.

Chemically, midazolam HCl is 8-chloro-6-(2-fluorophenyl)-1-methyl-4 H -imidazo[1,5-a][1,4]benzodiazepine hydrochloride. It has the empirical formula of`C 18 H 13 ClFN 3 ·HCl, and a molecular weight of 362.25.

It is used as a premed for medical procedures and also in anaesthetics. It is not used for it's anxiolytic or hypnotic effects. It induces a strong anterograde amnesia (it prevents the formation of new memories):

In one adult study, when tested the following day, 73% of the patients who received VERSED intramuscularly had no recall of memory cards shown 30 minutes following administration; and 40% had no recall of the memory cards shown 60 minutes following administration.

Elimination of the parent drug is via hepatic metabolism, therefore it should be used with caution (as with most benzos) in people with a history of liver disease or excess alcohol intake.

Half-life is significantly increased in the obese, the elderly, those with congestive cardiac failure, liver failure and renal failure.

It is 3-4 X more potent (per mg) than diazepam.

As an im premedication dose is approx 5mg 1 hour prior to procedure.
When given intravenously it is given as a titrated dose, 1mg at a time, every few minutes until the desired level of sedation is achieved.

As it is given parenterally the risk of severe respiratory depression is very real. This is associated with a very real risk of periods of anoxia (and subsequent brain damage). Paradoxical agitation is also common. People who have been given midazolam often become disinhibited sexually.

As with all benzodiazepines a physical tolerance to and dependance occurs rapidly.

An antidote is available (Flumazenil). This is only indicated for iatrogenic (doctor-induced) benzo overdose as in benzo-dependant patients it will rapidly lead to withdrawal (and potentially life-threatening seizures).

SWIJ has a single recreational experience of midazolam (iv).

She had a trusted sitter and the dose was titrated carefully. She was benzo naive at the time and used approx 1mg every 5 mins until 6mg were reached: At this point she was euphoric, sedated and having auditory and "thought process" hallucinations. She felt very sexual. Her sitter (female) reports that she was rather "frisky" also;)

The entire experience lasted approx 45 mins, with about an hour of grogginess after and a headache shortly after that. A degree of amnesia was present, but she retained the flavour of her experience. With hindsight this was an incredibly stupid and dangerous thing for her to do and certainly not an experience she would repeat.

[Psych0naut]

I know that Dormicum is a incredibly strong anestetic.They used it to keep my grandad in a coma for a week.I think they used a solution of 40-50 ml per day, so it's very strong...

[dr ACE]

SWIM thinks Rohce currently is more than capable of produceing pill forms of this benzo -just my 2 cents:-

http://www.erowid.org/pharms/show_image.php?i=other/benzodiazepine1.jpg

[Jatelka]

:o SWIJ stands corrected: It comes in 7.5mg and 15mg tablets and they are indeed produced by Roche.

[mark_v]

SWIM tried the blue 15 mg from Roche shitloads of times.
This is by far the most strong benzo SWIM ever tried and SWIM tried A LOT !
30 mg hits you like a train within a few minutes.
Very good sleeping pill, but can be used recreational in a lower dose.

[Richard_smoker]

I've heard of this being offered in a pill form from other countries (outside the US). Could you please be more specific in terms of the effects from 15 and 30mg tabs?

Could you describe its onset and duration of action? what does it feel like? and what would you compare it to in terms of valium, xanax, klonopin, bromazepam??

thanks, RS

[dr ACE]

I've heard of this being offered in a pill form from other countries (outside the US). Could you please be more specific in terms of the effects from 15 and 30mg tabs?

Could you describe its onset and duration of action? what does it feel like? and what would you compare it to in terms of valium, xanax, klonopin, bromazepam??

thanks, RS

everything you need to know is right here:-

http://en.wikipedia.org/wiki/Midazolam

icasea any one following this thread is wondering i have learnd allot about benzodiazepines since surfing the electronic hyber space man!

[Forthesevenlakes]

swim, long ago, received an IV of midazolam and meperidine while getting his teeth pulled. unfortunately swim does not remember much of the experience. he remembers holding a conversation for a couple minutes after the IV started, and after that, had a two hour blank in his memory. he was told that he remained conscious the entire time, and was talking through the surgery. he was told also that what he was saying made very little sense, but that he looked like he was having the time of his life saying it.

swim would be interested in trying this rare benzo again, albeit at a much lower dose.

[Jatelka]

It's (http://It's) really not that rare: In the UK it is a standard pre-procedure drug, used to induce amnesia. It is available elesewhere in the world as a sleep aid.

SWIJ has a single experience of midazolam: See this post...

http://www.drugs-forum.co.uk/forum/showpost.php?p=139860&postcount=19

[wearestardust]

I've never heard of 30mg tablets - only 7,5mg and 15mg. I know of two brands, DORMICUM and FLORMIDAL, and they are the strongest sleeping pills SWIM has ever used. Sledgehammer stuff. They are recommended for insomnia where anxiety and night panics are experienced. They hit SWIM like the old barbiturates used to. Fast and heavy.
WAStardust

[hgwell]

swim was given two vials of 50mcg fentanyl / 2 mg versed vials along with 2 of 50mg demerol/2 mg versed for a total of 8mg versed and 100 mcg fentanyl /100 mg of demerol IV. swim have a mediium tolerance to xanax and opiates and this felt great.swim fell asleep after about 1 hour and the doctors were amazed at how much it took to sedate swim. swim lied about having had been prescribed fent patches before so theyed give swim more opiates. This was for a heart surgery. good experience but wish i was more awake. the anesthisia nurse was awsome she just get injecting until i told her i felt it. wish they were all like that.

[Psych0naut]

I've had many different hypnotic benzodiazepines, and SWIM has even more experience with different downers, but Dormicum(midazolam) still is the best knock-out sleep aid existing. I have prescription for 15mg Dormicum, the blue bombers by Roche, and without tolerance, half a tablet taken sublingually would put me out in less than 30 seconds. Even with tolerance, just 1 tablet of 15mg would suffice to put me out. SWIM also aquired some Dormicum and generic midazolam ampoules, each ampoule contained 3 ml solution of 5mg/ml, the same ones as used in anesthesia. Just 2,5mg taken intramusculary, and SWIM will have full amnesia for more than an hour, and with full amnesia, I mean no recollection of any memories, at all. It's insane. Some people who are consciously sedated with midazolam start to act weird, histeriously laughing about nothing, or talking nonsense, it doest certainly have much more paradoxical side-effects than any other benzodiazepine, together with triazolam.

[matthewfoo]

My meerkat tells me this:

"i've got a slab each of 7.5s and 15s roche. I never had any sense of high or bliss or euphoria for that matter. But it is really excellent if u need to get some immediate slp, esp if ure coming down hard on something. 15 knocks me out in less than 15 min. If i fight the sleepiness while on dorm, and go about doing things, 95% of the time i would not be able to recall what i did, eg, phone calls i made, i couldnt recall having any conversations with anyone. btw i crashed my car into a van becos i was kept dosing off subcontiously from just a dose of 7.5 plus 15. I took it thinking the 20 min ride back would be just nice for me to KO at home, but quite obviously i should have taken them when i got home instead. I do have a tolerance for diazepams,nitrazepams and alprazolam, but midazolam (roche dorm), somehow just knocks me out cold fast. my advice, dont take mida, be it versed or dorm, if u intend to go out. Maybe its just me."

Any thoughts

[soma]

SWIM was IV'ed with 15mg of midazolam and he thinks its about as strong as 8mg of alprazolam. He has absolutely no clue what happened for a 4 hour period surrounding the dose, and it takes him around 8mg of alprazolam to do this to him. He is very very tolerant to benzodiazepines.

[matthewfoo]

SWIM was IV'ed with 15mg of midazolam and he thinks its about as strong as 8mg of alprazolam. He has absolutely no clue what happened for a 4 hour period surrounding the dose, and it takes him around 8mg of alprazolam to do this to him. He is very very tolerant to benzodiazepines.

swim gets this only with midazolams, hardly any euphoria, just pure cluelessness, with alprazolam, swim gets at least a buzz when taken with mild opiates. But with midazolams, swim does not feel any buzz even when taken with opiates, in fact midazolam killed swim's opiate buzz. At least with vallies and nitras or xannies, swim gets a calming effect when taken with opiates and eases come downs.