View Full Version : Drug info - Buspirone
miller77
30-03-2005, 16:13
Has any one heard of BuSpar ? If you have is it any good.
it sucks.
It's used mostly as an anti-anxiety drug. I've seen it given to people on ritalin a lot. I deffinately wouldn't classify it as much of a downer though. Unless you have anxiety problems you probably won't be interested in buspar. It has no affnity for benzo receptors and does not effect gaba binding. This pretty much eliminates any benzo-like effects.
Buspar works on serotonine.
camiroquai
03-04-2005, 18:13
I hate buspar. The only effects I got in up to 5 pills (unknown mg) was a weird feeling in my face. I didn't like it.
miller77
03-04-2005, 19:37
Buspar works on serotonine.
what is that?
Serotonine is a neurotransmitter(a substance which your body uses in the process of transmitting signals to cels.f.e. in your brain) 80% of your serotonine is in your bowels, 10% in your blood and 2% in your brain. Serotonine affects sleep, mood, hunger, dreams, hallucinations, bloodpressureand much more. There are various kinds of serotonine. All with different functions. For example: MDMA (the substance which should be in XTC) has a primairly effect on serotonine, uplifting your mood, making you dreamy, etc. Edited by: Alfa
The odd thing is buspar's action is not entirely understood. Saying that it works on seratonin is pretty nondescript, but it is all one can really say. Well, it does has some affinity for d2-dopamine receptors as well - as if that is saying much. All that can really be said is the buspar is not in any way a recreational drug.
Have you looked at the structure for buspar? theCAS is something like 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-aza-spirodecane-7,9-dione monohydrochloride, depending of course on which ring you start your naming from.
miller77
04-04-2005, 18:26
thanks you have been very help full
miller77
04-04-2005, 18:27
has any one here heard of topamax? and is t any good?
BuSpar vs. Topamax (http://www.drugs-forum.com/forum/forum_posts.asp?TID=9477&PN=1)
Gahaba22
06-04-2005, 05:47
I would not suggest taking BuSpar for recreational purposes. The exact mechanism of BuSpar's action is unknown
young poppa
15-04-2005, 01:49
this drug is fu(king wild, snort one of them and u feel lke u got hit by a truck, terrible taste when snorted but no burn, ive only done the white bars, which i beleive is the highest dosage pill, they are sold sometimes as zanax
BusPar treats anxiety and Topomax is used to provide long term relief to
treat migraine headache patients.
luckyatl13
02-05-2005, 03:40
i only took one pill of buspar(not sure wat mg)but it made me dizzy and me head feel like it had alot of pressure on it. like if u go underwater realy deep.
I was on Buspar for several months, it works well for anxiety but takes about 2-5 days to take full effect. Buspar has no recreational value to it and even when used at doctor perscribed doses can have side affects thats are unplesent and anoying. stear clear of this drug unless your looking for long term anxiety relief
Its Serotonin not serotoninE ... hehe
raven3davis
07-10-2005, 09:12
this drug is fu(king wild, snort one of them and u feel lke u got hit by a truck, terrible taste when snorted but no burn, ive only done the white bars, which i beleive is the highest dosage pill, they are sold sometimes as zanax
You got xanax mixed up with buspar man. I think you are referring to the slang name for xanax, which is bars, and yea, bars are quite powerful little puppies.Edited by: raven3davis
this drug is fu(king wild, snort one of them and u feel lke u got
hit by a truck, terrible taste when snorted but no burn, ive only done
the white bars, which i beleive is the highest dosage pill, they are
sold sometimes as zanax
You got xanax mixed up with buspar man. I think you are
referring to the slang name for xanax, which is bars, and yea, bars are
quite powerful little puppies.
actually, the highest dosage buspar [buspirone] pill does come in bar form also.
personally, i'm not so sure buspar has recreational value. my doc
has me taking 2 of the bars every night for anxiety. i actually
tried tapering off of them because i felt they weren't doing much, but
i felt so horrible that i just went back on again and all was
okay. anyhow, this is just my own personal experience.
Emperiorjack
03-12-2005, 11:00
I think buspar works better has an anti-depressant then an Anti-anxiety
med. I remember I took six of the 30mg bars just to see what would
happen and it made my anxieties worst.http://www.drugs-forum.com/forum/smileys/smiley5.gif
jesusfreak666er
08-12-2005, 02:57
buspar is a crappy antianxiety medication, it is only ever effective for people i refer to as "benzodiazapine virgins"... not only is it extremely weak the only way to abuse is to crush and snort... ooo and believe me u will feel it... u will wish u hadn't it. It makes u feel like shit, sick, tired but not in a pleasureable way... u will count the seconds till it goes away.
pharmapsyche
03-01-2006, 08:31
I came across 15 buspirone (the generic name for BuSpar) 15mg bars once. I decided to take them as directed, 1 bar a day. I was anxious to see what kind of anti-anxiety effect I would experience. Of course, I was also curious to see whether buspirone had any abuse potential (at the recomended dosage.) I have mild anxiety and after 5 days I hadn't noticed anything different. There was a mild sensation of anxiolytic-like action, but I wondered then just as I wonder now if it was just placebo. I didn't experience any side effects personally, although I wouldn't be surprised if many people did since this drug seems to be somewhat a mystery. Buspirone works on the serotonin receptor 5-HT1a receptor, and also has dopamine D2 antagonist/agonist properties. These properties usually result in the release of prolactin. All in all, my asessment of buspirone is that in a theraputic setting, it might have mild to substancial benefits but as a drug of abuse, none whatsoever. I'd like to note, however, that after about 7 days of taking buspirone, I was driving in my car and felt much more cheerful then normal. This is what I mean when I say 'placebo' vs. buspirone's effects.
Herbal Remedy
12-02-2006, 10:22
Swim recently came across a few pills (oval shaped, white, "658" engraved on one side, "watson" engraved on the other-double stacked shape).
Swim's research concluded that the pills are Buspirone Hydrochloride, a drugs used to treak anxiety. But that is all the info swim could obtain, and he thought this was the best place to bring his questions. He was wondering if anyone had any experience/insight/knowledge about this drug and the best method of using it recreationally. Any responses would be appreciated, thanks, peace...
pharmapsyche
16-02-2006, 11:07
The pill you mentioned is indeed buspirone hydrochloride 10 milligrams. Buspirone has a potent anti-anxiety effect that usually becomes apparent within 3-5 days of treatment. Buspirone is different from other anxiolytics, such as the benzodiazepines, meprobamate or the barbiturates because instead of acting on GABA receptors it acts on serotonin receptors (specifically, it is a 5-HTP1A receptor agonist.) It also indirectly influences dopamine receptors. I'll write more later.
Herbal Remedy
16-02-2006, 23:57
Im worried that the way the pill works will make it hard for me to feel the effects of regular xanax or other drugs so right now im holding off on it. I might be wrong though, thanks for the reply (and any future replies!), peace...
pharmapsyche
17-02-2006, 02:50
Good news, Remedy: cross-tolerance to benzodiazepines, barbiturates, and alcohol does not exist with buspirone: GABA-mediated effects are lacking. It works by interfering with the activity of serotonin in the brain, acting as a 5-HT1A receptor partial agonist. Additionally, it acts as a mixed agonist/antagonist on post-synaptic dopamine receptors. So there could be some interactions with serotonin or dopamine agonist/antagonists but not with the GABAergic drugs.
Buspirone is such an interesting compound. Pharmaceuticals never fail to amaze me with their unique properties and theraputic potentials.
Herbal Remedy
20-02-2006, 00:25
thanks for the replies benzenerings, i can now enjoy myself with an easy mind... i'll write up a report for sure! peace....
Buspirone is an anti-anxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.
It is a white crystalline, water soluble compound with a molecular weight of 422.0. Chemically, buspirone hydrochloride is 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-aza-spiro[4.5]decane-7,9-dione monohydrochloride. The empiric formula is C21H31N502
Tablets are available containing 5 mg, 10 mg, 15 mg, or 30mg of buspirone hydrochloride. The 5-mg and 10-mg tablets are scored so they can be bisected. The 15-mg and 30-mg tablets are scored so they can be either bisected or trisected. They contain the following inactive ingredients: Colloidal silicon dioxide, lactose, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate. The 30-mg also contains iron oxide.
The mechanism of action is unknown. Buspirone differs from benzodiazepines in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effects that are associated with more typical anxiolytics. In vitro studies have shown that buspirone has a high affinity for Serotonin (5-HT1A) receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding. It also has moderate affinity for brain D2-dopamine receptors. Some studies suggest that buspirone may have indirect effects on other neurotransmitter systems.
Buspirone HCl is rapidly absorbed after oral administration and undergoes extensive first pass metabolism.
It has nonlinear pharmacokinetics. Thus, dose increases and repeated dosing may lead to somewhat higher plasma levels.
In man, approximately 95% of buspirone is plasma protein bound.
It is metabolized primarily by oxidation producing several hydroxylated derivatives and a pharmacologically active metabolite, 1-pyrimidinylpiperazine (1-PP).
Up to 60% of a dose is excreted in the urine and up to 40% faecally excreted. The average half-life after a single dose is 2-3 hours.
Buspirone HCl is indicated for the management of anxiety disorders or the short-term relief off the symptoms of anxiety.
The effectiveness of Buspirone in long-term use, that is, for more than 3 to 4 weeks, has not been demonstrated in controlled trials. There is no body of evidence available that systematically addresses the appropriate duration of treatment.
The recommended initial dose is 15 mg daily (5 mg 3 times a day). The maximum daily dosage should not exceed 60 mg.
Common adverse effects include: Dizziness, nausea, headache, nervousness, lightheadedness, fatigue and paradoxical anxiety.
Other adverse effects include: Myalgia, dream disturbance, sore throat, tinnitus, urinary retention, reduced libido, impotence, and weight gain.
Rarely Buspirone has caused: Anaphylaxis, alopecia, deranged liver function tests and thrombocytopenia (low platelet count).
There is a theoretical concern that because of it's affinity for dopamine-receptors that Buspirone could lead to Parkinsonism and other movement disorders. This has not been confirmed in clinical studies.
Buspirone is NOT a controlled substance.
In both human and animal studies, buspirone has shown no potential for abuse or diversion and there is no evidence that it causes tolerance, or either physical or psychological dependence.
Concomitant use of MAOI's is contraindicated. Other contraindications: Hepatic or renal impairment, nursing mothers.
No deaths have been reported in humans either with deliberate or accidental overdosage of buspirone. Toxicology studies of buspirone yielded the following LD50 values: mice, 655 mg/kg; rats, 196 mg/kg; dogs, 586 mg/kg; and monkeys, 356 mg/kg. These dosages are 160 to 550 times the recommended human daily dose.
Richard_smoker
27-02-2006, 22:23
Whoever stated that buspirone is a potent anxiolytic is completely mistaken. That's the first I've ever heard anyone refer to this compound as potent.
It is, in fact, one of the weakest drugs known to man. Ask someone who has ever prescribed buspirone... Patients who tend to improve are as likely to be cured by placebo effect.
pharmapsyche
04-03-2006, 12:56
I competely disagree with you. For your information, I got the term 'potent anti-anxiety effect' from the Pocket PDR 2005. Buspirone takes a little while to demonstrate any noticable positive changes but it is certainly a very novel and potent anti-anxiety drug, when taken as directed for severak weeks. I did an experiment over 15 days taking 1 15mg buspirone every morning. There were dramatic and significant anxiolytic activity observed around the 12th day, with minimal sedation or mental clouding. Despite the drugs low bioavailability (%5) it is a safe and very effective anxiolytic. DO YOUR HOMEWORK RICHARD SMOKER
Richard_smoker
04-03-2006, 23:32
The pocket PDR is made up of advertisements made BY the drug companies. Like I said, ask a psychiatrist or family physician or someone else who has actually used the drug on their patients. They will laugh when you try and explain to them that it is potent.
In fact, it is a running joke within the medical community to "Thank God for Buspirone!" Now, they can just prescribe Buspirone for drug-seeking benzo addicts. So for God's sake, don't ask YOUR doctor if it's potent! of course he'll say it is. He's not THAT stupid!
Be careful. There are much better references out there than the PDR. Pocket Pharmacopoeia is probably the most popular book. Epocrates is the most popular for palm. But PDR is drug company propaganda--the paperwork that they report to the FDA and the whole page of information on the reverse side of magazine ads. Very biased toward the product.
As far as you're concerned, I'm glad that the drug worked for you.
As far as your commandment to me do my homework, I'm not even going to comment on this, except to say: "DON'T USE ALL CAPS, ESPECIALLY WHEN YOU'RE TELLING ME WHAT TO DO, and also try not to base your knowledge of a compound soley upon something you found in a biased source and your own single experience." It is the experience of MANY (thousands) that I take as significant as this signifies statistical power. The experience of a single person means almost nothing. In fact, this is no different than someone saying "I took ginseng, and after 3 weeks, I began to notice that my overall sense of well-being had improved!" This says absolutely nothing about the effectiveness of ginseng as a drug.
Try using medline, pubmed, gratefulmed... one of these will have actual studies, but you must be careful that p value is <.05, that there aren't any blatant flaws, and preferrably the study should be independently run after FDA has already approved the drug. Otherwise, even a single flaw signifies that the study's results are meaningless and should have been thrown out because of a failure to acknowledge the null hypothesis as true (I believe this is a Type I error).
--sorry, didn't mean to sound attacking, was just offended by the homework comment. Yes, you are correct that it is an anxiolytic, and yes, it takes days or weeks to take effect. Since the drug apparently worked on you, this means that you are in the 'good' category of people with anxiety issues. For people with truly disabling issues of anxiety, Buspirone won't even put a dent in it. So, thank your lucky stars that your problem was treatable with the relatively benign, non-addicting Buspirone. Aside from this, I am sorry for jumping down your throat. I didn't mean to sound as mean as I did.
pharmapsyche
05-03-2006, 05:03
I am humbled
bewilderment
27-03-2006, 00:27
I was prescribed buspar a long time ago for anxiety (I was also on paxil and remeron at the time) and on the second day that I took it I became severely depressed and somewhat delusional and quit speaking entirely. I immediately stopped taking it.
swim started taking buspar as an anti anxiety helper, but it unfortunatly had a reverse effect on swim. swim could not go to sleep. that is actually how swim found this site, swim couldn't sleep one night. had to stop takin em cause after years of not sleeping from the ugliness of meth, it brought back unwanted memories in the wee hrs of the mrng. lorazepam's are working better for swim now.
upperdecker
24-12-2006, 00:05
Buspar is a piece of shit. SWIM was prescribed it for anxiety and it just made it worse.Also, there is no recreational benefit using this drug. Unless you find feeling dizzy or uncomfortable fun, this drug is completely useless. Alot of doctors themselves say its about as effective as a placebo.
SWIM was also prescribed Buspar at one point (for panic attacks), for which it helped not in the slightest. Not even a tiny, minute, minor dent in SWIM's panic attacks or general anxiety level. All he remembers is some dizziness that added to the overall unpleasantness of the situation.
The Mama
25-12-2006, 20:52
Swim was also prescribed buspar many years ago. It also did absolutely nothing to help her situation. Except she remembers that it made her mouth so dry she could spit cotton balls!
SWIdr has recently had a suggestion to switch from his benzo treatment, to buspirone for anxiety, and since he didnt know what buspirone was, he declined. Reading this thread, it seems it was a good thing he declined. SWIddr wonders if a combo of buspirone and a smaller than usual dose of a benzo would help alot with anxiety even more than either one alone. He would guess it would, but it would probably help people who need benzos for their anxiety but are becoming addicted to their prescribed benzodiazapines. SWIdr knows other combos have been used to help with anxiety so this would probably work.
SWIdr has recently had a suggestion to switch from his benzo treatment, to buspirone for anxiety, and since he didnt know what buspirone was, he declined. Reading this thread, it seems it was a good thing he declined. SWIddr wonders if a combo of buspirone and a smaller than usual dose of a benzo would help alot with anxiety even more than either one alone. He would guess it would, but it would probably help people who need benzos for their anxiety but are becoming addicted to their prescribed benzodiazapines. SWIdr knows other combos have been used to help with anxiety so this would probably work.
Some people say buspirone is only helpful in conjunction with certain SSRI antidepressants. Can't confirm/deny (haven't researched it myself), just passing on the info.
bewilderment
31-12-2006, 21:51
SWIdr has recently had a suggestion to switch from his benzo treatment, to buspirone for anxiety, and since he didnt know what buspirone was, he declined. Reading this thread, it seems it was a good thing he declined. SWIddr wonders if a combo of buspirone and a smaller than usual dose of a benzo would help alot with anxiety even more than either one alone. He would guess it would, but it would probably help people who need benzos for their anxiety but are becoming addicted to their prescribed benzodiazapines. SWIdr knows other combos have been used to help with anxiety so this would probably work.
Here's some info on how Buspar is commonly believed to work:
The mechanism of action of buspirone is unknown. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivo when tested in preclinical models.
Buspirone has moderate affinity for brain D2-dopamine receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems.(from a well known prescription drug info site
The good news would be that there should not probably not be any cross-tolerance between benzos and the Buspar. However, since the pharmacology of the two differ so much, I'm not sure that one would enhance the effects of the other although I suppose taking two anti-anxiety meds may have the effect of getting rid of anxiety more effectively.
But, as evidenced by this thread, Buspar can tend to have quite a few undesirable side-effects.
I've also heard the info about taking Buspar with SSRI's, in particular:
The anecdotal evidence amongst people we know who have taken BuSpar is it works fine, as long as you're taking an antidepressant along with it. By itself it did nothing. But there was a noticeable effect when BuSpar is added to an antidepressant. It doesn't seem to matter which neurotransmitters are getting messed with, as long as it's an already working antidepressant. BuSpar blocks the 5HT 1a receptor, which is believed to help block anxiety aggravated by antidepressants. Bristol-Myers-Squibb. For more information: http://www.bms.com/business_development/data/twsbrochurepi.pdf (from: another forum)
Personally, I was prescribed Buspar along with Paxil (an SSRI) about six years ago and went into some strange psychosis around the second or third day of taking the Buspar. But, my reaction was quite atypical and may have had something to do with the Paxil as well as I never felt quite right on Paxil and had numerous strange side effects while I was on it.
hmmmm - SWIM is sensing a buspar theme!! after SWIM had her first baby, she never "rebounded" into feeling like "herself" months afterwards. luckily, the only thing that made her feel better was getting absorbed in the new little bundle; however, this just resulted in getting even more lost in the end. after seeing a psychiatrist and a therapist, SWIM tried several different antidepressants/dosages, etc., for both depression and anxiety (paxil, remeron, cymbalta, xanax, lorazepam, clonapine, zoloft, buspar ... hmmmm - think that's all of them - what misery!).
after working up to 60 mg. of paxil for a couple months, SWIM's depression is better and the anxiety is verrrrrrrrrrrrrrrry slowly following suit. the 1 mg. of xanax worked the best on the anxiety, but SWIM was having pretty bad memory loss (like weeks are missing, not just hours). doctor tried out the time-released xanax so SWIM didn't have to take them 2 or 3 times a day and would hopefully not have the memory issues. after the first dose, SWIM passed out and got 911'd to the emergency room (ended up OK but obviously am not taking the benzo's anymore).
is there a question in all this, you're wondering?? :) since not being able to take the benzos anymore, SWIM's doctor suggested maybe a beta blocker, but wanted to try buspar first. SWIM isn't really feeling any better or worse and have been on them for about a month. does anyone have a similar situation and if there's a positive scenario, how long did it take to kick in and was there an antidepressant also involved?
thanks so much for your time and shared experiences!
Swim has two causes where he has dealt with BuSpar. The first one was cold night in a parking lot at V-Dubs where Swim thought he was purchasing 10 MG generic oxycontin. Having to much trust in the dealer was a bad thing for him. When he got home Swim crushed then moved on to snorting two of them. Right after he knew it wasn't real & felt like he was going to haft to admit himself into an E.R. Room.
The second time was through a relative who gave Swim two white generic Xanax bars & a couple BuSpar. He doesn't recall much of that day but from what he remembers and was told he was slow, calm, and hungry.
weedshouldblegal
25-01-2007, 19:02
yah i took buspar for anxiety for just about a month and quick because it wasnt helping i probaly should have kept on it longer tho i didnt know it did anything tho evryone told me u cant over dose on it.so idk and yall tell me : can u over dose on prozac?? i know u cant but these kids at school tell me u can
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IkBenDeMan
01-04-2007, 11:15
As SWIM left his high school graduation, he was kicked a few BuSpars. It was quite some time ago, but he believes they were 10 mgs. He took three of them, and snorted a 40 of oxy and took a 40 orally. The BuSpar added some kind of rolling effect, not dissimilar to the feeling of MDMA.
they make swim twichty,he also read somewhere during testing that alot of animals went into convulsions and died(<---non confirmed).while yes they give you a buzz and help with anxity swim dosent think anything that causes blephorospasms and his arm jumping a foot in the air randomly is good!
upperdecker
07-04-2007, 18:58
SWIM use to be prescribed Buspar for anxiety and they did absolutely nothing. Infact SWIM thinks they made him more anxious. They definitely make you kind of dizzy though, SWIM wouldn't call it a buzz.
Here's some info on how Buspar is commonly believed to work:
(from a well known prescription drug info site)
The good news would be that there should not probably not be any cross-tolerance between benzos and the Buspar. However, since the pharmacology of the two differ so much, I'm not sure that one would enhance the effects of the other although I suppose taking two anti-anxiety meds may have the effect of getting rid of anxiety more effectively.
But, as evidenced by this thread, Buspar can tend to have quite a few undesirable side-effects.
I've also heard the info about taking Buspar with SSRI's, in particular:
(from: another forum)
Personally, I was prescribed Buspar= along with Paxil (an SSRI) about six years ago and went into some strange psychosis around the second or third day of taking the Buspar. But, my reaction was quite atypical and may have had something to do with the Paxil as well as I never felt quite right on Paxil and had numerous strange side effects while I was on it.
I asked my Psyciatrist is i could do a trial run on BUspar and he OKed it as long as i kept taking a much smaller amount of Fluexetine (Prozar try Wow, I am really glad now a decided to jst go with the traditional prescription doctor prepertatio: SSRI & Benzodiazepine. The first year of so the Prozec did fine and gelp, but thn it got weird. Maybe it just my drugs' interations, but it did make me feel almost like "numb" emotionally. Even right after my dearest dad passed away I:( could barely cry and let my emotions, it was a real tough time....Thats why I slowely weened myself off of that sh*t and now iv been Prozec, or basically any other SSRI's for that matter. I feel much better now, but unnfortunatly I still get depressed on a daily basis.
But anyways Im getting a 2nd, or is ia a 3rd oppinion on being diagnosis with Manic Deprsseion AKA Bi-Polar, because alot of people saying a seem like one:crazy . So my reactions to SSRI's may be cuased by that (possible) diagnosis and i should be taking something else instead, so who knows, it could have nothing to do with the Buspar.
One last thing, if you really cant get to sleep and are clinically depressed, SWIdr waould then suggest Remeron (Mirtazapine), It produces weak/moderate SSRI reults, but it will knock you out 15-30 minuyes afer you takr it. The downside though is it does cause somewhat of a hangover, but coffee and or yerba mate really helped me wake up fast it the morning. Update us on how is goes!!
PS: Apologies for my handwriting/gramer....I am a little out of it:D
bewilderment
13-04-2007, 17:29
One last thing, if you really cant get to sleep and are clinically depressed, SWIdr waould then suggest Remeron (Mirtazapine), It produces weak/moderate SSRI reults, but it will knock you out 15-30 minuyes afer you takr it. The downside though is it does cause somewhat of a hangover, but coffee and or yerba mate really helped me wake up fast it the morning. Update us on how is goes!!
Swim used to take Remeron for insomnia. It worked rather well, but it should also be noted that it caused her to gain about 35 lbs. over the course of 6 months or so. So, if one worries about that sort of thing then be forewarned.
Swim used to take Remeron for insomnia. It worked rather well, but it should also be noted that it caused her to gain about 35 lbs. over the course of 6 months or so. So, if one worries about that sort of thing then be forewarned.
Yes, Remeron, did have some nasty side effects. It knocked SWIdr out (which was good) but he also good a good twenty pound, not to mention he felt like a zombie the first couple of hours he woke up (and he was on a semi-small dose 15mgs). Since then SWIdr is SSRI, SNRI, etc free....except for tramadol.
A new entry has been added to Drugs Archive
Description: Originally published in Drug Metabolism and Disposition
Concludes that CY3PA4 is responsible for metabolising Buspirone
To check it out, rate it or add comments, visit Cytochrome P450 3A-Mediated Metabolism of Buspirone in Human Liver Microsomes (Zhu et al, 2005) (http://www.drugs-forum.com/forum/local_links.php?linkid=2692)
The comments you make there will appear in the posts below.
A new entry has been added to Drugs Archive
Description: Originally published in JPET
Buspirone and it's metabolite act as partial 5HT-1a receptor agonists in vivo
To check it out, rate it or add comments, visit Pharmacokinetic-Pharmacodynamic Modelling of Buspirone and it's Metabolite 1-(2-Pyridiminyl)-piperazine in Rats (Zuideveld et al, 2002) (http://www.drugs-forum.com/forum/local_links.php?linkid=2693)
The comments you make there will appear in the posts below.
SWIM was considering giving Buspirone a try, but it now seems that it its efficacy is just too good to be true, as was suspected.
SWIM suspects that he has a general anxiety disorder, and was going to go to his doctor to discuss this possibility after researching all of the available (drug) treatments. He didn't want to start down the benzodiazepine route, but it seems now that might be no other option other than psychotherapy, if Buspirone is indeed as relatively useless as it seems.
Perhaps he'll give Kava Kava a try...
Swim found buspirone to be worse than useless. He felt dizzy, anxious, and aggressive- and swim is NEVER aggressive. As far as I'm concerned, Benadryl would be a better anti-anxiety agent than this crap.
Psychonautica
24-08-2007, 05:04
For a while swim was prescribed xanax for acute anxiety and became quickly addicted. It improved anxiety temendously, but swim's psychiatrist switched her to buspar to avoid a long term benzo prescription/addiction.
Buspar has done absolutely nothing for swim's anxiety, even after prolonged use. Swim has tried daily doses of 5-HTP and GABBA in the past to help ease amphetamine withdrawal and believes it had more potent effects than buspar. Buspar has no recreational value whatsoever and feels that even it's medical value is minimal.
She's sure her psychiatrist, and many other psychiatrists everywhere only prescribe buspar at all to get rid of benzo addicts. Acute anxiety seems only to be treated successfully with benzos such as xanax or klonopin.
Buspar is for suckers.
Laudaphun
29-12-2007, 19:38
I was once prescribed buspar (buspirone) at a gradual increase of dosage until 15mg 3 times daily was reached. At this point I was overjoyed at leaving the doctor's office with something for anxiety besides one of the common modern anti-depressants. I asked the dr. if there were any side-effects and she replied, "there really aren't any."
... well, I began taking it and very quickly noticed that it would sometimes give me a feeling that is hard to describe, sort of like a slight numbness/tingling feeling in my face and at the same time a dizzy sort of feeling to the point where I would have to go lie down. I began to do some reading, I quickly discovered that taking buspar(buspirone) on a full stomach increases the bioavailability a great deal. Thus, if I took it on a completely empty stomach I did not get these side effects, but if I took it with any food in my stomach or ate soon after taking it, I was highly likely to get these side-effects.
So, I continued to take it and take it and after a month I returned to the dr. and reported no decrease in my anxiety. She replied that I had just reached the therapeutic level in my blood. I thought, ok... so then without telling her my side-effects and what I had read about the bioavailability on a full stomach compared to an empty stomach, I asked her if it mattered at all if I took it on an empty stomach or a full stomach... she said no. I pressed her further without telling her that I disagreed and she insisted that it did not matter.
After I had been taking it a month or so, it randomly began causing anxiety attacks. Not often, but often enough to want to stop taking it. I pressed on, thinking this was my final hope now that we had exhausted the SSRIs, SNRIs, etc. Finally after returning to the dr. a couple months after I started taking it, I told the dr. that I could not tell any reduction in my anxiety and that if there was any at all it was very slight... that's when she told me that if it did reduce any anxiety that it would be very slight... I did not tell her of the side-effects as she so confidently told me there were none originally and I didn't want to tell her that she was wrong.
I then quit taking it and for me at least it was a totally worthless drug.
violentcheetah
08-01-2008, 00:56
When I was 14 my parents had me on this stuff but I never took it and was young and stupid and gave it out. That was over 10 years ago so whatever. But a couple years ago SWIM was going through a big ski stage and snorted a little of it and was like "Blam! Right down." SWIM said that the feeling was not enjoyable at all when done solo but aided in the coming down off cocaine. And SWIM noticed time was off. It seemed as if 30 min. had gone by and it was only 5. Weird stuff.