View Full Version : Drug info - Alprazolam (Xanax) Powder
same question here, I've heard that you can't snort it, buy I beg to
differ. Maybe it was soething else? anyway. What can
be done wiht PURE Xanax powder (not rushed pills)
Edited by: namidua
raven3davis
31-10-2005, 06:49
It can definitely be snorted, but be very careful with the dose. Not sure about IM or IV because swim has heard benzos arent very water soluable.
same question here, I've heard that you can't snort it, buy I beg to differ. Maybe it was soething else? anyway. What can be done wiht PURE Xanax powder (not rushed pills)
Xanax is soluble in ethanol but not water at physiological ph. Hope this helps: (edited by me for clarity)
Snorting xanax reduces its bioavailability by up to 66% and no less than 33%. Obviously this depends on a number of factors such as mucusal membrane functionality, tolerance to triazolo Benzodiazepines with a heterocycline group unique to Xanax or alprazolam. My suggestion is that if you are this desparate for BDZr 1-6 (that we know of) activation for specific GABA instructions for CNS inhibitory mechanisms than chew the pill and keep it under your tongue for five minutes, then just swallow what is left. It should take a mere 15 minutes to feel some effects. THE PROBLEM WITH SNORTING XANAX IS THAT IT IS NOT READILY H2O SOLUBLE.
Additionally drugs which are poorly water soluble do not cross the blood brain barrier effectively (or at all) which means you require higher doses (and thus more chance of adverse effects such as respiratory depression) to achieve your desired effect.
Water soluble benzos include midazolam ,flurazepam and flunitrazepam.
SWIM stumbled upon some pure xanax (alprazolam ) powder, he has a milligram scale so dosing will not be a problem but he still wants to find a better way to dose other then that and liquid dosing, SWIM was wondering if anyone was familiar with some method of cutting this powder with some kid of filler so he could pack capsules or press pills if he wanted to, hopefully somebody can help SWIM out with this concept.
Benzeneringz
10-08-2006, 01:14
Why don't you want to use the liquid dosing method? I guess just use flour.
jesusfreak666er
10-08-2006, 02:09
swim thinks cutting is a poss. but one must make sure they do a sufficent job in mixing, It would be a pain to be off in measurements. Sift the powders together a few times and take it slow, but liquid dosing sounds much more efficient.
if you do it wrong and you have a "hotspot" in your powder it could kill someone pretty easily. keep that in mind.
:joint:
So far SWIM got these ideas from another forum:
"The alprazolam capsules I've already prepared were made dissolving it in alcohol, filling the capsules and evaporating. The capsules look a little bit funny after the process and I only had 96º denaturalized alcohol. I don't really like ingesting bitrex even if its in such tiny quantities. I was discussing where to buy pure alcohol here (its illegal to sell it without denaturalizing it) and some chemist friends suggested a method to mix it with inert powder in a secure way. Will explain it when I have tried it.
Basically consists on putting it on a container and mixing it (turning the container around) for some hours with a material with a similar density. Then adding more mixing agent and letting it mix more time. After that filling the caps. It's what usually is done in labs but at home in a more ghetto way."
SWIM is wondering how he would go about finding something with a similar densitiy to do this with, if anyone can elaborate SWIM would be extremely grateful.
sourceman
10-08-2006, 08:58
So far SWIM got these ideas from another forum:
"The alprazolam capsules I've already prepared were made dissolving it in alcohol, filling the capsules and evaporating. The capsules look a little bit funny after the process and I only had 96º denaturalized alcohol. I don't really like ingesting bitrex even if its in such tiny quantities. I was discussing where to buy pure alcohol here (its illegal to sell it without denaturalizing it) and some chemist friends suggested a method to mix it with inert powder in a secure way. Will explain it when I have tried it.
Basically consists on putting it on a container and mixing it (turning the container around) for some hours with a material with a similar density. Then adding more mixing agent and letting it mix more time. After that filling the caps. It's what usually is done in labs but at home in a more ghetto way."
SWIM is wondering how he would go about finding something with a similar densitiy to do this with, if anyone can elaborate SWIM would be extremely grateful.
I will do my best to explain this process, but I am interested in hearing what you chemist friend told you about mixing it..
To start off with, find a filler/binder that has roughly the same molecular weight (MW). Swim thinks Alprazolam is around 310 (just chexked and it is 308.8 lol.. not a bad guess!!) SWIM remembers from doing trandermal experiments with this powder.. Now once SWIY finds the binder/filler the next step is to figure out the mass off he needed filler for the capsules to be filled or pill to be pressed. SWIM assumes SWIY knows how to do this. If not , ask.
OK. Let's say that each capsule will hold 500mg filler. 100 Caps is what SWIY wan't to make, then 50g filler is needed. powder the filler finely with mortar and pestal. place in sealable container.
if the desired dose is 2mg/cap, then 200mg is needed. This is best done by throug liquid measurement, SWIM believes. 99.7 % pure alcohol can hold40mg/ml alprazolam. So 5ml is needed for this process. Draw up 5ml solution.
This is where people have different views. one method is to add the solution to the filler, draw another ml or 2 of CLEAN alcohol and flush syringe. mix container wekk, and let evaporate. Then grind in the mortar and pestal again making sure to mix very thoroughly.
Another method is to let it evaporate in the bast of the mortat and pestal and then add the filler and mix vigorously.
SWIM likes the first method.
Next fill the caps!
If a large batch is desired, aquire a parts tumbler (that is used to sand, grind, polish etc different objects. it is a drum that lays on it's side and rolls over and over. if sand is in ther and you put rusty metal, it will remove the rust and polish the metal). These can be purchased very cheaply for $20-50. Add the filler/binder, add the alcohol mix, throw in some LARGE Stainless Steel ball bearings and let it run for at least 12 hours. The longer the better! this generates heat by the tumbling, so it evaporates the alcohol fairly fast.
Also, if SWIY needs to know how to get alcohol to 99% LMK!
raven3davis
10-08-2006, 12:45
Just dillute the alp powder into the grain alcohol. 20mg/ml should seem about right. So each 1/10ml should contain 2mg. Get a syringe and draw up 10units, which is the same as 1/10ml. Those ten units should be holding 2mg. just shoot that in your mouth and have a good time. Chase with a beer if necessary. Hide well so no one will mistakingly take a shot or something.
jesusfreak666er
10-08-2006, 17:19
denatured alcohol is horrible idea, its not drinkable, and leaves residue once evaporated swim believes, they add stuff to the alc so they can sell it tax free. swim doesn't know if the amount ur using is dangerous but still not a good idea.
sourceman
10-08-2006, 20:08
^^ Raven, you are right about the grain alcohol. It will hold 20mg/ml in solution very easily. Grain is 190 proof, which means that it is 5% water. you wouldn't believe how much to 5% effects the alcohol in getting the alprazolam into solution. If water is removed by desiccation, you can reach 40mg/ml. Either way, it works well. If a large batch is being made or it is being injected in capsules, the minimum amount of liquid is desired.
^JF666r - After looking over the posts, there seems to be no mention of denatured alcohol. That is correct though, one could die or go blind if one injested that substance. The poisenous substance is called Methanol (aka, methyl alcholol or wood alcohol). it is added to Ethanol (drinkable type) to denature it, making it undrinkable.
raven3davis
10-08-2006, 21:52
So if you had inactive powder in a capsule, could you squirt the 10 units (.1ml) into the capsule holding the powder so the powder would absorb the liquid and it would be laced with your alprazolam. Would this work, or would the capsule break open? These are all good ideas, but mixing the powder first with a filler seems like the most time consuming and complicated method.
You might as well just get a really good scale and individually dose each cap.
sourceman
10-08-2006, 22:13
So if you had inactive powder in a capsule, could you squirt the 10 units (.1ml) into the capsule holding the powder so the powder would absorb the liquid and it would be laced with your alprazolam. Would this work, or would the capsule break open? These are all good ideas, but mixing the powder first with a filler seems like the most time consuming and complicated method.
You might as well just get a really good scale and individually dose each cap.
Adding .1ml to cap wil work fine. Also, if one is prescibed a med in capsule form, one could inject the .1ml into the capsule and swallow! SWIM know many people who injest liquid's this way. Also, yes, the powder would be laced. The capsule shouldn't break open.
Also, mixing powder first with filler is more time consuming but yeilds a better end product SWIM believes. If making many for personal consumptin it is much faster this way than injecting 100's of caps, and easier on the hands!
SWIM decided to continue on this project, only one problem, in his state pure 200 proof alcohol is nowhere to be found, he knows that he could use methanol but wants to do the liquid dosing and fill empty capsules with the solution and methanol is toxic so that would not be safe for consumption and anything under 200 proof will cause the capsule to break down and turn into a gel like goo.
Any suggestions would be greatly appreciated.
Forthesevenlakes
13-09-2006, 07:38
200 proof, to swim's understanding, converts to about 190 proof after exposure to air, due to absorption of water from the environment. if pure ethanol would be acceptable to put in empty capsules, then everclear should also work, since that is 190 proof.
Psych0naut
13-09-2006, 19:19
if you do it wrong and you have a "hotspot" in your powder it could kill someone pretty easily. keep that in mind.It won't kill someone "pretty easily".Though it can knock someone out, benzodiazepines are very safe when overdosed, except when thery're taken with other CNS depressants.
Forthesevenlakes
13-09-2006, 21:04
other CNS depressants including alcohol. hm, maybe alcohol isnt the best thing to be dissolving the benzos in, then...although if swiy is only ingesting a minute amount it may not be too harmful.
Sklander
15-09-2006, 21:51
1/10ml of alcohol = 2MG = One Xanax (Bar)
That amount of alcohol will have no effect whatsoever. In fact, the alcohol will probably evaporate leaving only Alprazolam powder.
SWIM just picked up a few Marshmellows that have been injected with 2MG Alprazolam each. A very creative friend of SWIM's came up with this! GummyBears have also been used with success. Marshmellows seem to absorb best, though.
Forthesevenlakes
15-09-2006, 23:24
SWIM just picked up a few Marshmellows that have been injected with 2MG Alprazolam each. That would make one hell of a cup of hot chocolate. Swim hopes this idea doesnt spread though, swiy may be using them responsibly but the last thing the forum needs is people asking questions on how to shoot up junk food =]
SWIM recently came into a fortune in alprazolam powder. Unfortunatly he doesn't have a .5mg scale. So he wants to try dissolving a known amount in a liquid and dosing that way. SWIMS question is this. Would leaving 1g of alprazolam in a liquid over a long period of time degrade it? The liquid SWIM is considering is mouth wash (swim is under 21 and cannot buy alcohol)
rxbandit
18-10-2006, 05:45
swim notes that swim has left aprazolam powder for 2 weeks with out any notable change in kool-aide drink. swim would recomend getting a somewhat precise scale or weighing as close to 100 mg's on a normal scale and then dilluting it heavily so any small inaccuracys wont become tragic. 4 mg's of this powder knocked swim out for 18 hours within 30 minutes or so.
swim has used water, shaking before consumption with multiple succesful dosings without much difficulty...
so alprazolam is somewhat soluble in water? If so swim will just use that. What he wants to do is dissolve the powder into some solvent then put drop with 2mg onto pieces of cotton, paper, cloth, or any other absorbant material and place that into pills when dry. Does this seem feasable?
Forthesevenlakes
18-10-2006, 09:10
SWIM had just typed out a response to this, and then accidentally shut the firefox window, so here goes again...
Alprazolam at 37°C was 0.045 mg/mL soluble in water. This is to say, not very soluble at all. So dissolving in water would not work that well. It would be more soluble in alcohol but there would be the risk of evaporation, so it would not work as a long term storage solution if put onto cotton really. Unless SWIY wants the alcohol to evaporate and then puts the cotton into pills, but the cotton would already have to be precut into small sections, SWIM thinks. Maybe it'd be soluble in DMSO or PEG if swiy has access to those?
But really as stated before the only TRULY safe way to measure this out is with a good scale...xanax is active even at low doses so it would pay to be safe, even 2 mg is enough to knock some people out!
Correct me if I'm wrong, but would it need to be soluble in water? SWIY could just shake the liquid thoroughly to put it into suspension, then immediately do whatever it is to be done with it, i.e. treat it as if it were dissolved. That should work well enough.
Forthesevenlakes
18-10-2006, 09:34
SWIM's not sure that it would even go into suspension effectively in water, plus it seems too risky to try this with a huge amount of alprazolam unless someone else can confirm that this would work for sure.
SWIM does have access to dmso but no cash left over after the alprazolam. Also swim would like to avoid the suspension method it seems to be begging for an overdose. Is alprazolam soluble in isopropal alcohol? If not does anyone know how many mg per ml dissolve in ethanol and at what temperature? If that amount is acceptable swim will just use mouth wash.
Correct me if I'm wrong, but would it need to be soluble in water? SWIY could just shake the liquid thoroughly to put it into suspension, then immediately do whatever it is to be done with it, i.e. treat it as if it were dissolved. That should work well enough.
Suspension is very different than dissolution in this case. Even if shaken, it will still be a non-homogeneous mixture, so decanting a certain volume of liquid will not yield a certain dosage of crystal. The amount will vary depending on the randomness of the distribution and one's ability to get the crystals to "go with" the alcohol however it is divided. One would do better to avoid the hassle of dissolving it and just eyeball a small amount, or measure the smallest amount possible on a scale and divide fractionally from there. If done this way, start at the smallest amount possible and make sure you allow enough time for effects to manifest before titrating upwards.
Still, as Forthesevenlakes mentioned, a 1-2mg scale is really necessary to do this safely. If SWIY is going to be experimenting with psychoactives in this way, invest the money! They're available for less than $100 shipped.
The best method SWIM came across so far is dissolving 1g per 100mL of grain alcohol (95%), resulting in a 10mg/mL solution. This could be measured accurately with any small syringe, even the kind used for babies at department stores (oral syringes). This source mentioned that other alcohols wouldn't dissolve it completely, but that might be debatable.
SWIM can sympathize with the difficulty in obtaining alcohol, especially nearly-pure grain alcohol that isn't available everywhere. Please use extreme caution, and if anyone tries a different alcohol or method of decanting, start with very small amounts and make sure you can see the amount of powder the first couple times so there aren't any surprises.
Oh yeah, and enjoy yourself :smoking:
Does anyone happen to know how soluble alprazolam is in ethanol and methanol. If I can get that data I will be able to decide whether or not I can use mouthwash (which has both methanol and ethanol) as a solvent.
Someone on another forum claimed to get a 20mg/ml solution with 80% proof vodka.
With regards to methanol: SWIJ has seen a figure of 8.2mg/ml but is unclear how reliable that source is.
Any SWIY got a Merck Manual?
radiometer
19-10-2006, 20:06
Not sure if this is the part you need, but nonetheless a helpful web reference:
http://www.merck.com/mrkshared/mmanual/home.jsp
Thanks to both of you, thats the info I needed. I also found out alprazolam breaks down in acidic conditions. So I have decided to abandone the idea of mouth wash, to many varibles. Instead I will suck up the cost and buy some white lightning which should produce consitant results.
Sklander
22-10-2006, 10:14
Everclear worked great for a friend of SWIM's. SWIM believes he did it so that he could inject the solution into marshmellows, gummy worms, jelly beans... etc.
"What are those marshmellows you have their, son?"
"I really like marsh mellow's, officer... Care for you?"
:)
Swim is about to get 10 grams of alprozolam and 10 grams of diazepam powder. Swim does not have that great of a scale with him at the time (swims good scale is at his fathers). Swim knows he can measure 1 gram accuratly. Is there any other way to measure dosages of 10mg valium and 2mg xannax without a scale if you know u have 1 gram. I know neither is soluble in in water but i know alprozolam is in 95% aclohol
Wow! now thats alot of benzos! Why are they in powder form? Wouldnt SWIY rather get the actual pill so he knows exactly what hes getting? Anyways SWIY is on his own there with the measuring. Eyeballing it out is the only way SWIdr can think of measuring it, and boy oh boy is that gonna be hard for the alprazolam. Why dont you eyeball out the diazepam (easier to do, since larger dosage) and save he alprazolam until you get back to our father's house?
Psych0naut
28-12-2006, 13:20
Regarding potency, Alprazolam and DOI are practically the same, now SWIY won't eyeball DOI won't he ?
Diazepam is in SWIMs opinion too potent to eyeball as well, SWIY will be needing a mg scale to measure doses for both.
1 gram of more of Alprazolam dissolved in a known quantity of fluid would be good, or measuring out individual doses of Diazepam.
Jetelka, you may want to double check your ref. because the following Drug Data lists oxazepam as almost insoluble in water.
http://chrom.tutms.tut.ac.jp/JINNO/DRUGDATA/29oxazepam.html
Old thread, I have been corrected on this previously (edited anyway)
Psych0naut
06-07-2007, 12:44
There is a water soluble version of oxazepam on the markt as well, oxazepam hemisuccinate. Loprazolam is water soluble as well.
brooooooo!
24-01-2008, 23:08
anyone have any experience with this stuff?
as far as dosing goes...how much is equal to say a bar of xanax?
Matt The Funk
24-01-2008, 23:28
2mg....A "xanny bar" has 2mg of alprazolam. Never had experience with pure powder but plenty with the pills. Don't see how they would differ much.
JaWill88
24-01-2008, 23:40
yeah it's quite simple. to reach a dosage equivelant to a 1mg xaxax (alprazolam) bar, than 1mg of alprazolam would be needed. 2mg of powder of a 2mg xaxax bar. kind of obvious lol. unless the powder is cut or something.
One will need an accurate scale for these measurements.. a second best would be to know how much one has.. ie. 30mg total, then divide into 30 piles of 1mg each.. but when it comes down to potent substances with dosing in the mg and even sub-mg level, it really absolutely is worth investing in a scale that can read mg and a set of weights or whatever you wanna call them- often available in head shops etc.- for accurate taring of said scale. Good luck!! :)
old hippie 56
24-01-2008, 23:53
Might be advisable to get some accurate scales to do the measuring, kinda hard to eyeball powder.
brooooooo!
24-01-2008, 23:55
ok thanks. i didnt know if the pure powder was equal to the bars. as in the amount of alprazolam in a bar, i wasnt sure if a 2mg bar was actually 2mg of pure xanax. thanks all.